Fellowship - Development of novel diagnostic technology for arteriosclerosis based on a detection of microRNAs

Refernza Lavoro: 000084

Luogo: Japan

Data di Chiusura: 06/12/2019

Annuncio inserito il: 30/08/2019

Retribuzione: C10M JPY

Ruolo: Toshiba Fellowship

Categoria: Research & Development

  which complement the incomplete MBD, and achieve both the shortest design turn-around-time (TAT) and the best system performance. Also in the system operations, the aging performance deteriorations and their variations are difficult to predict in the design process are detected by IoT and AI. The results are not only reported to the system operator but also act as feedback to the next system design, and the system reliability is further improved. This research is in the cross research domain, and the chances that the applied researcher is familiar with all the related layers are slim. The Fellowship researcher will pursue research based-on his/her wide, deep knowledge, rich ideas and systematic thinking regardless of one’s major. This research area is likely to be one of the most important ones for the next generation of Toshiba with its wide variety of power electronics businesses. Moreover, Toshiba is the best environment for such research activity considering the existence of all the related layers of power electronics technologies and applications.

Development of novel diagnostic technology for arteriosclerosis based on a detection of microRNAs

MicroRNA has attracted attention in the medical field for the potential to be an effective diagnostic biomarker of diseases and drug targets. Toshiba is developing cancer diagnostic technology based on the detection of microRNAs, through a collaboration with National Cancer Center Japan. Since the microRNA detection technology is also applicable to the diagnosis of other diseases, we are now investigating suitable target diseases, following on from cancer.

Description of Research
Arteriosclerotic diseases (myocardial infarction, cerebral infarction, etc.) are our potential  target diseases due to their high mortality rates and associcated high national medical expenditures. The aim of this program is (1) to search a good diagnostic maker of microRNA for arteriosclerosis, (2) to clarify the mechanism of microRNAs related to the disease, (3) to propose a novel diagnostic technology in order to realize advanced precision medicine through the development of highly precious detection of microRNAs.

Required Knowledge and Skills
Candidates should possess expertise in molecular biology of microRNA. It is preferable that applicants  are medically qualified..

Related papers
[1] Hashimoto K., Inada M., Ito K. Multiplex Real-Time Loop-Mediated Isothermal Amplification Using an Electrochemical DNA Chip Consisting of a Single Liquid-Flow Channel. Anal. Chem. (2019) 91, 3227-3232. doi: 10.1021/acs.analchem.8b05284.
[2] Hashimoto K., Inada M., Ito K. Preliminary evaluation for a novel voltammetric analysis of targeted nucleic acid by combining electrochemical DNA chip and digital loop-mediated isothermal amplification. J. Electroanal. Chem. (2017) 807, 104-107. doi: 10.1016/j.jelechem.2017.11.040.
[3] Hashimoto K, Inada M, Ito K. A novel voltammetric approach for real-time electrochemical detection of targeted nucleic acid sequences using LAMP. Anal. Biochem. (2017) 539, 113-117. doi: 10.1016/j.ab.2017.10.019.